Sensitive-stage embryo irradiation affects embryonic neuroblasts and adult motor function

Abstract Background Cranial radiation therapy for treating childhood malignancies in the central nervous system or accidental exposure may result neurological side effects surviving adults. As tissue homeostasis is maintained by stem cells, understanding effect of on neural cells will provide clues managing effects. Drosophila embryos were used as a model whose sensitivity to irradiation-induced cell death changes from sensitive resistant stage during development. Objective at radiation-sensitive irradiated various doses and was tested regarding appearance apoptotic embryonic lethality. Cell fates called neuroblasts (NBs) adult motor function after irradiation also investigated. Result Irradiation resulted dose-dependent increase number containing 75 min treatment starting 3 Gy. Embryonic lethality assayed hatch rate induced 1 Gy irradiation, which did not induce death. Notably, no apoptosis detected NBs up 2 h high 40 At low Gy, marked Dpn Klu decreased an unidentified mechanism regardless status embryo. Furthermore, but locomotor defects Conclusion survived while other parts underwent higher than within treatment. Three hours minimum dose decreased, adults exhibited ability.